blood born pathogen

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Modulation of CD8 and CD3 by HIV or HIV antigens

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Abstract

To investigate whether human immunodeficiency virus (HIV)-1 and HIV-1 antigens modulate surface and cytoplasmic CD8 or CD3, as well as CD4, we used cell permeabilization reagents, surface/cytoplasmic fluorescent staining, multiparameter flow cytometric techniques and an in vitro culture system in which relatively few lymphocytes are actively infected with HIV.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Absence of human T-cell lymphotropic virus type I coinfection in human immunodeficiency virus-infected hemophilic men

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Abstract

Concern for transmission of human T-cell lymphotropic virus, type 1 (HTLV-1) infection to recipients of infected cellular blood products has prompted development of tests to eliminate blood units with HTLV-I antibodies. Most hemophilic men from the United States became infected with human immunodeficiency virus (HIV) before HIV donor screening and before blood products were processed to inactivate the virus.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Potential effect of revising the CDC surveillance case definition for AIDS

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Abstract

The Centers for Disease Control (CDC) revised the surveillance case definition for acquired immunodeficiency syndrome (AIDS) in August, 1987. To determine the impact of this revision, information was extracted from the medical charts of the 630 patients receiving comprehensive medical care as of 1980 at 6 haemophilia treatment centres, and who were therefore likely to have been infected with human immunodeficiency virus (HIV).… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

HTLV-III/LAV antibody status of spouses and household contacts assisting in home infusion of hemophilia patients

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Abstract

Thirty-four adult and pediatric hemophilia A and B patients and 50 nonhemophilic members belonging to 28 families were enrolled in August 1984 in a study of human T cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody status and T cell subpopulation numbers.… Read more

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HTLV-I antibody status in hemophilia patients treated with factor concentrates prepared from U.S. plasma sources and in hemophilia patients with AIDS

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Abstract

Serum samples from 85 Austrian hemophilia patients treated with lyophilized factor concentrates prepared from U.S. plasma sources, 24 hemophilia patients from Georgia on a home therapy program with factor concentrates, and 10 U.S. hemophilia patients with acquired immunodeficiency syndrome (AIDS) were analyzed by two different methods for the presence of antibodies to the major internal antigen of human T-cell leukemia virus I (HTLV-I) p24.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Immune status of blood product recipients

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Abstract

Persons with hemophilia are at risk of the acquired immunodeficiency syndrome (AIDS), and clinically asymptomatic hemophiliacs have shown a high incidence of AIDS-like immune abnormalities, facts leading to speculation that many hemophiliacs have been exposed to the AIDS agent through their blood products.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Acquired immunodeficiency syndrome (AIDS) in hemophiliacs

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Abstract

From mid-1977 to mid-1983 the Centers for Disease Control (CDC) has received reports of more than 2,100 cases of acquired immunodeficiency syndrome (AIDS). These cases had either biopsy-confirmed Kaposi’s sarcoma or a biopsy or culture confirmed life-threatening opportunistic infection, without an identifiable cause of immunosuppression.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Acquired immunodeficiency syndrome (AIDS) in hemophiliacs

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Abstract

From mid-1977 to mid-1983 the Centers for Disease Control (CDC) has received reports of more than 2,100 cases of acquired immunodeficiency syndrome (AIDS). These cases had either biopsy confirmed Kaposi’s sarcoma

or a biopsy or culture confirmed life-threatening opportunistic infection, without an identifiable cause of immunosuppression.… Read more