differentiation

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Transient antibody deficiency and abnormal t-suppressor cells induced by phenytoin

by

Abstract

The lack of normal  B-cell  differentiation in patients with acquired or congenital antibody  deficiency may reflect abnormalities inherent in cells of B-lymphoid  lineage or may  involve abnormalities of regulatory (suppressor) cells. Circulating suppressor T cells,  which interfere with IgM secretion in a plaque-forming-cell assay, have been found in 60 per cent of these patients,  but their role in the pathogenesis of the disease is unclear. … Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Quantitation of human thymus/leukemia-associated antigen by radioimmunoassay in different forms of leukemia

by

Abstract

Using a radioimmunoassay, increased levels of a human thymus/leukemia-associated antigen (HThy-L) have been detected in leukemic cells and plasma from most patients with E-rosette-positive acute lymphoblastic leukemia (ALL) and a number of patients with E-rosette-negative ALL, acute myeloblastic leukemia (AML), acute monomyelocytic leukemia (AMML), and acute undifferentiated leukemia (AVL).… Read more