HIV

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The course of the epidemic of acquired immunodeficiency syndrome in the United States hemophilia population

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Abstract

The time course of the epidemic of acquired immunodeficiency syndrome (AIDS) as it has occurred in the US hemophilia population is examined using surveillance data collected by the Centers for Disease Control (CDC). These data indicate that the epidemic course in hemophiliacs is distinguishable from that in the homosexual/bisexual and intravenous drug-using populations in at least one respect–the epidemic in the hemophilia population is characterized by a lack of consistent increase in the number of new AIDS cases in successive time intervals.… Read more

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Effects of exposure to factor concentrates containing donations from identified AIDS patients. A matched cohort study

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Abstract

We compared recipients of eight lots of factors VIII and IX voluntarily withdrawn from distribution because one donor was known to have subsequently developed the acquired immunodeficiency syndrome with a nonexposed cohort matched by age, sex, and factor use. The factor VIII recipient cohorts did not differ in prevalence of antibody to human immunodeficiency virus (HIV) (exposed, 75%; nonexposed, 86%), T-cell subset numbers (median: exposed, 619 T-helper cells per cubic millimeter; nonexposed, 659 T-helper cells per cubic millimeter), T-helper to T-suppressor ratios, or immunoglobulin levels.… Read more

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HTLV-III/LAV-seronegative, virus-negative sexual partners and household contacts of hemophiliacs

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Abstract

Public concern about the transmissibility of human T-cell lymphotropic virus type III/ lymphadenopathy-associated virus (HTLV-III/LAV) has been heightened by several reports suggesting the existence of an antibody-negative, virus-positive state in some asymptomatic sex partners of persons who are antibody-positive.  We recently evaluated 88 household members and/or sex partners of persons with hemophilia and found that only two nonhemophiliacs were HTLV-III/LAV antibody-positive.  … Read more

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Conjugal transmission of HTLV-III and lymphadenopathy in Christmas disease

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Abstract

The risk of conjugal transmission of the HTLV-III/LAV virus associated with the acquired immunodeficiency syndrome (AIDS) in patients with hemophilia is unknown.  To date, only a few   instances of proven exposure to HTLV-III have been reported among sexual or family contacts of   patients with hemophilia.  … Read more

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HTLV-III/LAV antibody and immune status of household contacts and sexual partners of persons with hemophilia

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Abstract

We evaluated the human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody and immune status of 88 persons living with and/or sexual partners of 43 hemophiliacs, 12 of whom had AIDS, five of whom had AIDS-related complex (ARC), 17 of whom were clinically well but HTLV-III/LAV antibody positive, and nine of whom were well and HTLV-III/LAV antibody negative.… Read more

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HTLV-III exposure during cardiopulmonary resuscitation

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Abstract

To the Editor: There have been no confirmed occupation-related cases of AIDS in health care workers in the United States. We have been following two nurses who participated in mouth-to-mouth re­suscitation of a patient with the AIDS-related complex, who was positive for human T-cell lymphotropic virus Type- III/lymphade­nopathy-associated virus (HTLV-III/LAV), and we here report their seronegativity nine months after exposure.… Read more

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HTLV-III/LAV antibody status of spouses and household contacts assisting in home infusion of hemophilia patients

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Abstract

Thirty-four adult and pediatric hemophilia A and B patients and 50 nonhemophilic members belonging to 28 families were enrolled in August 1984 in a study of human T cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody status and T cell subpopulation numbers.… Read more

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Lymphadenopathy-associated virus antibodies and T cells in hemophiliacs treated with cryoprecipitate or concentrate

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Abstract

Evidence for exposure to lymphadenopathy-associated virus (LAV) was investigated in 48 patients with hemophilia, 15 of whom had been treated exclusively with single-donor cryoprecipitate. The prevalence of antibodies to LAV in all patients was 53% in 1983 and 63% in 1984, while in patients treated only with cryoprecipitate, the prevalence was 31% in 1983 and 40% in 1984.… Read more

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Human T-lymphotropic retrovirus type III/lymphadenopathy-associated virus antibody. Association with hemophiliacs’ immune status and blood component usage

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Abstract

We studied the human T-lymphotropic retrovirus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody status of 234 factor VIII concentrate recipients, 36 factor IX concentrate recipients, 69 long-term recipients of frozen packed red blood cells, and 47 persons not receiving routine transfusion therapy.… Read more

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HTLV-I antibody status in hemophilia patients treated with factor concentrates prepared from U.S. plasma sources and in hemophilia patients with AIDS

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Abstract

Serum samples from 85 Austrian hemophilia patients treated with lyophilized factor concentrates prepared from U.S. plasma sources, 24 hemophilia patients from Georgia on a home therapy program with factor concentrates, and 10 U.S. hemophilia patients with acquired immunodeficiency syndrome (AIDS) were analyzed by two different methods for the presence of antibodies to the major internal antigen of human T-cell leukemia virus I (HTLV-I) p24.… Read more

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Immune status of blood product recipients

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Abstract

Persons with hemophilia are at risk of the acquired immunodeficiency syndrome (AIDS), and clinically asymptomatic hemophiliacs have shown a high incidence of AIDS-like immune abnormalities, facts leading to speculation that many hemophiliacs have been exposed to the AIDS agent through their blood products.… Read more

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Acquired immunodeficiency syndrome (AIDS) in hemophiliacs

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Abstract

From mid-1977 to mid-1983 the Centers for Disease Control (CDC) has received reports of more than 2,100 cases of acquired immunodeficiency syndrome (AIDS). These cases had either biopsy-confirmed Kaposi’s sarcoma or a biopsy or culture confirmed life-threatening opportunistic infection, without an identifiable cause of immunosuppression.… Read more

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Clinical aspects of child abuse

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Jason J

In:  Current Diagnosis, 7th edition, R.B. Conn, editor.  W.B. Saunders Co, Philadelphia, 1984.

 … Read more

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Perspective comprehension of AIDS

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Evatt BL, Jason J

Proc 4th Int Symp HT 1984; p 97‑102.… Read more

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AIDS in hemophilia

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Evatt BL, Chorba T, McGrady G, Jason JM.

 

Proc 4th International Symp on Hemophilia Treatment, Tokyo, Japan, 1984; p 1‑14.… Read more

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Acquired immunodeficiency syndrome (AIDS) associated with transfusions

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Abstract

Of 2157 patients with the acquired immunode­ficiency syndrome (AIDS) whose cases were reported to the Centers for Disease Control by August 22, 1983, 64 (3 per cent) with AIDS and Pneumocystis carinii pneumonia had no recognized risk factors for AIDS.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Acquired immunodeficiency syndrome (AIDS) in hemophiliacs

by

Abstract

From mid-1977 to mid-1983 the Centers for Disease Control (CDC) has received reports of more than 2,100 cases of acquired immunodeficiency syndrome (AIDS). These cases had either biopsy confirmed Kaposi’s sarcoma

or a biopsy or culture confirmed life-threatening opportunistic infection, without an identifiable cause of immunosuppression.… Read more