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Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Spontaneous cytokine production and its effect on induced production

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Abstract

Cytokines regulate cellular immune activity and are produced by a variety of cells, especially lymphocytes, monocytes, and macrophages. Multiparameter flow cytometry is often used to examine cell-specific cytokine production after in vitro phorbol 12-myristate 13-acetate and ionomycin induction, with brefeldin A or other agents added to inhibit protein secretion.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

The effects of iron deficiency on lymphocyte cytokine production and activation: preservation of hepatic iron but not at all cost

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Abstract

Worldwide, over 40% of children have iron deficiency anaemia, frequently associated with infections. Certain cytokines are involved in both immune activation/response to infection and iron transport/metabolism. We therefore assessed the relations among iron deficiency, cytokine production and lymphocyte activation markers in 142 hospitalized Malawian children.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Intracellular cytokines in the acute response to highly active antiretroviral therapy

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Abstract

OBJECTIVES: Successful highly active antiretroviral therapy (HAART) is usually associated with a rapid decline in HIV plasma RNA levels and a gradual increase in CD4 T cells. We examined whether changes in cytokine production and profile precede other immunological changes and whether these might occur in temporal association with plasma HIV RNA changes.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Cytokines and malaria parasitemia

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Abstract

The balance between pro- and antiinflammatory cytokines may be important in malaria presentation and outcome. Malaria tends to be more severe in children than in adults, presumably because partial immunity develops with age. However, the full nature of, and age-related differences in, anti-malarial immunity are unknown.… Read more