Immunodeficiency

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Clinical predictors of bloodstream infections and mortality in hospitalized Malawian children

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Abstract

BACKGROUND: In sub-Saharan Africa, bloodstream infections (BSI) are a major cause of pediatric mortality. Because of limited resources and facilities in these developing countries, treatment often must be based solely on clinical observations and patient history and includes the use of broad spectrum antimicrobials, a factor in the emergence of antibiotic resistance.… Read more

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Evidence for a shift from a type I lymphocyte pattern with HIV disease progression. Hemophilia Growth and Development Study

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Abstract

Whether a shift from a type I (cell mediated) immune profile occurs with progressive HIV-related immune dysfunction is a matter of heated debate.

We analyzed data for 333 HIV antibody-positive (HIV+) and -negative (HIV-) hemophilic children/adolescents, to examine whether the relationships among immunologic parameters and vaccine-related serology supported a shift with advancing HIV infection.… Read more

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Immune and serologic profiles of HIV-infected and noninfected hemophilic children and adolescents. Hemophilia Growth and Development Study Group

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Abstract

OBJECTIVES: To assess relationships among the effects of HIV on hemophilic children and adolescents’ immunologic parameters and vaccine-related serology.

METHODS: We analyzed data from extensive baseline immunologic evaluations of 207 HIV antibody-positive (HIV+) and 126 HIV antibody-negative (HIV-) hemophilic children and adolescents.… Read more

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Infectious disease-related deaths of low birth weight infants, United States, 1968 to 1982

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Abstract

Infant mortality rates in the United States are higher than in any other developed country. Low birth weight (LBW) is the primary determinant of infant mortality.

 

Despite city, state, and federal programs to prevent LBW, decreases in infant mortality in the 1980s appear to be largely secondary to improved survival of LBW infants rather than to a decline in the rate of LBW births.… Read more

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Infectious diseases: preventable causes of infant mortality

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Abstract

After almost a century of improvement, the rate of decrease in US infant mortality rates began to level off during the period of 1982 to 1984. Rates actually increased in some states. Because much of the decline in infant mortality in this century can be attributed to advances in infectious disease treatment and prevention programs, we evaluated the current impact of infectious diseases on infant mortality.… Read more

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An historical perspective on controversy surrounding the international code of marketing of breast‑milk substitutes

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Jason JM, McGrady GA.

In: Clinical Obstetrics – A Public Health Perspective.  B P Sachs & D Acker (eds).  PSG, Inc. Boston, MA, 1985.

ISBN 0-88416-513-2… Read more

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Immune status of blood product recipients

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Abstract

Persons with hemophilia are at risk of the acquired immunodeficiency syndrome (AIDS), and clinically asymptomatic hemophiliacs have shown a high incidence of AIDS-like immune abnormalities, facts leading to speculation that many hemophiliacs have been exposed to the AIDS agent through their blood products.… Read more

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Acquired immunodeficiency syndrome (AIDS) in hemophiliacs

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Abstract

From mid-1977 to mid-1983 the Centers for Disease Control (CDC) has received reports of more than 2,100 cases of acquired immunodeficiency syndrome (AIDS). These cases had either biopsy-confirmed Kaposi’s sarcoma or a biopsy or culture confirmed life-threatening opportunistic infection, without an identifiable cause of immunosuppression.… Read more

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Perspective comprehension of AIDS

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Evatt BL, Jason J

Proc 4th Int Symp HT 1984; p 97‑102.… Read more

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AIDS in hemophilia

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Evatt BL, Chorba T, McGrady G, Jason JM.

 

Proc 4th International Symp on Hemophilia Treatment, Tokyo, Japan, 1984; p 1‑14.… Read more

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Mortality and infectious disease associated with infant-feeding practices in developing countries

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Abstract

This review examines the available studies bear­ing on the relation between infant-feeding mode and infectious illness in the populations of less­ developed countries.  In this review we will address the following key questions: (1) whether the method of infant feeding (breast v other) is associated with differences in rates of mortality, both overall and infectious, and in rates of infectious morbidity in less-developed countries; (2) whether differences exist between breast-feeding and other feeding methods in terms of infection rates for specific pathogens; and (3) whether the evidence is strong enough to suggest that any association is a causal one, ie, that the effect noted is actually caused by breast-feeding rather than other factors associated with rates of illness.  … Read more

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Acquired immunodeficiency syndrome (AIDS) associated with transfusions

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Abstract

Of 2157 patients with the acquired immunode­ficiency syndrome (AIDS) whose cases were reported to the Centers for Disease Control by August 22, 1983, 64 (3 per cent) with AIDS and Pneumocystis carinii pneumonia had no recognized risk factors for AIDS.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Acquired immunodeficiency syndrome (AIDS) in hemophiliacs

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Abstract

From mid-1977 to mid-1983 the Centers for Disease Control (CDC) has received reports of more than 2,100 cases of acquired immunodeficiency syndrome (AIDS). These cases had either biopsy confirmed Kaposi’s sarcoma

or a biopsy or culture confirmed life-threatening opportunistic infection, without an identifiable cause of immunosuppression.… Read more

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Transient antibody deficiency and abnormal t-suppressor cells induced by phenytoin

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Abstract

The lack of normal  B-cell  differentiation in patients with acquired or congenital antibody  deficiency may reflect abnormalities inherent in cells of B-lymphoid  lineage or may  involve abnormalities of regulatory (suppressor) cells. Circulating suppressor T cells,  which interfere with IgM secretion in a plaque-forming-cell assay, have been found in 60 per cent of these patients,  but their role in the pathogenesis of the disease is unclear. … Read more

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Diagnostic considerations in ataxia-telangiectasia

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Abstract

13 children with ataxia-telangiectasia were followed for 6 years. Unlike previously reported cases, these patients had progressive, debilitating neurological disease and slight pulmonary or infectious symptoms. Immunological dysfunction was variable and endocrinological defects were absent. Oculomotor findings, alpha-fetoprotein levels, and the incidence of chromosomal breakage were the most consistent parameters in the diagnosis of the condition.… Read more