major histocompatibility complex

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Detection of a novel binding site for T cell derived antigen binding proteins on thymic epithelial cell surfaces

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Abstract

The presence of helper T cells that do not recognize major histocompatibility complex encoded antigenic determinants but rather are specific for self idiotypic determinants led us to search for a mechanism by which such cells might be influenced by idiotype expressed on the surfaces of thymic epithelial cells.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

How T lymphocytes recognize antigen

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Abstract

One of the most intriguing problems in immunology during the years since the discovery of T cells as an entity has been the nature and specificity of their receptors. The study of the antigen-binding receptors in T cells has been plagued by a number of technical difficulties that are just now being solved.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2- and I-A restricted

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Abstract

We have investigated primary and secondary responses of mouse splenic T cells to strong mixed lymphocyte stimulating antigens controlled by the Mls locus using MHC-identical mixtures of cells. Our studies show that strong primary Mls-locus specific responses involve recognition of self I-A antigens, since BUdR and light suicide or F1 into parent radiation bone-marrow chimeras both demonstrate a preference of unprimed F1 T cells to respond to Mls-locus antigens associated with one parent’s MHC antigens.… Read more