serology

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Evidence for a shift from a type I lymphocyte pattern with HIV disease progression. Hemophilia Growth and Development Study

by

Abstract

Whether a shift from a type I (cell mediated) immune profile occurs with progressive HIV-related immune dysfunction is a matter of heated debate.

We analyzed data for 333 HIV antibody-positive (HIV+) and -negative (HIV-) hemophilic children/adolescents, to examine whether the relationships among immunologic parameters and vaccine-related serology supported a shift with advancing HIV infection.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Concordance of polymerase chain reaction with human immunodeficiency virus antibody detection

by

Abstract

To evaluate the correlation of detection of human immunodeficiency virus (HIV) by polymerase chain reaction (PCR) with detection of HIV antibody, 271 simultaneous serum and peripheral blood mononuclear cell samples were examined from 242 persons whose activities placed them at increased risk for HIV infection: 142 from homosexual men, 86 from hemophilic men, and 43 from heterosexual partners of HIV-infected persons.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Prevalence of human immunodeficiency virus type 1 DNA in hemophilic men and their sex partners. Hemophilia-AIDS Collaborative Study Group

by

Abstract

Polymerase chain reaction (PCR) was used to detect human immunodeficiency virus (HIV)-1 DNA in peripheral blood mononuclear cells to assess in hemophilic men whether any were HIV-seropositive but uninfected or seronegative but infected and in seronegative sex partners of seropositive hemophilic men whether any were infected.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Duration of human immunodeficiency virus infection before detection of antibody

by

Abstract

To estimate the duration and frequency of the period of HIV infection without detectable antibody, modelling techniques were applied to results of detection of HIV DNA by means of the polymerase chain reaction (PCR) and to data from cases in published reports.  … Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Risk of developing AIDS in HIV-infected cohorts of hemophilic and homosexual men

by

Abstract

The latency period and/or incidence of the acquired immunodeficiency syndrome (AIDS) may differ in persons infected with the human immunodeficiency virus by different routes or having different “cofactors.” We compared 79 hemophilic men in Pennsylvania and 117 homosexual and bisexual men in California, all having known dates of infection and long postinfection observation periods, to examine these hypotheses.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Sex practice correlates of human immunodeficiency virus transmission and acquired immunodeficiency syndrome incidence in heterosexual partners and offspring of U.S. hemophilic men

by

Abstract

We assessed the risk of human immunodeficiency virus (HIV) transmission from heterosexual seropositive hemophilic men to their female sex partners through an HIV serosurvey and questionnaire study conducted during 1984-1987. Five percent of 21 female partners of asymptomatic men and 11% of 35 partners of HIV-symptomatic (acquired immunodeficiency syndrome [AIDS], AIDS-related complex [ARC], peripheral generalized lymphadenopathy [PGL]) hemophilic men had been infected when first tested.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

The Epidemiology of AIDS

by

Abstract

Cases of the acquired immune deficiency syndrome (AIDS) were first reported in June and July of 1981, as clusters of Kaposi’s sarcoma and Pneumocystis carinii pneumonia among homosexual men. Since then, epidemiologic surveillance has been used by investigators and public health professionals to identify that an outbreak existed, to characterize the outbreak, and to determine and predict its extent and course.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

The course of the epidemic of acquired immunodeficiency syndrome in the United States hemophilia population

by

Abstract

The time course of the epidemic of acquired immunodeficiency syndrome (AIDS) as it has occurred in the US hemophilia population is examined using surveillance data collected by the Centers for Disease Control (CDC). These data indicate that the epidemic course in hemophiliacs is distinguishable from that in the homosexual/bisexual and intravenous drug-using populations in at least one respect–the epidemic in the hemophilia population is characterized by a lack of consistent increase in the number of new AIDS cases in successive time intervals.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

HTLV-III/LAV-seronegative, virus-negative sexual partners and household contacts of hemophiliacs

by

Abstract

Public concern about the transmissibility of human T-cell lymphotropic virus type III/ lymphadenopathy-associated virus (HTLV-III/LAV) has been heightened by several reports suggesting the existence of an antibody-negative, virus-positive state in some asymptomatic sex partners of persons who are antibody-positive.  We recently evaluated 88 household members and/or sex partners of persons with hemophilia and found that only two nonhemophiliacs were HTLV-III/LAV antibody-positive.  … Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Conjugal transmission of HTLV-III and lymphadenopathy in Christmas disease

by

Abstract

The risk of conjugal transmission of the HTLV-III/LAV virus associated with the acquired immunodeficiency syndrome (AIDS) in patients with hemophilia is unknown.  To date, only a few   instances of proven exposure to HTLV-III have been reported among sexual or family contacts of   patients with hemophilia.  … Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

HTLV-III/LAV antibody and immune status of household contacts and sexual partners of persons with hemophilia

by

Abstract

We evaluated the human T-cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody and immune status of 88 persons living with and/or sexual partners of 43 hemophiliacs, 12 of whom had AIDS, five of whom had AIDS-related complex (ARC), 17 of whom were clinically well but HTLV-III/LAV antibody positive, and nine of whom were well and HTLV-III/LAV antibody negative.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

HTLV I/II and HTLV III seroprevalence in blood product recipients

by

Abstract

Human T-cell leukemia virus type I (HTLV-I) has been strongly implicated as the etiology of adult T-cell leukemia (ATL), a T-cell type non-Hodgkin’s lymphoma with leukemic manifestations in Japan, the Caribbean, and the southeastern United States. The prevalence of serum antibody specific for one core antigen of HTLV-I, p24, has been found to be high in patients with ATL, and higher in relatives of these patients than in general population controls.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Human T-cell leukemia virus (HTLV-I) p24 antibody in New York City blood product recipients

by

Abstract

Human T-cell leukemia virus (HTLV-I)

is known to be associated with certain hematologic malignancies, and a related virus, HTLV-III/LAV, might be the cause of AIDS. Some persons with AIDS have had evidence of HTLV-I infection. Unrelated to these findings, it has been suggested that HTLV-I is transmitted via blood products.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

HTLV-III/LAV antibody status of spouses and household contacts assisting in home infusion of hemophilia patients

by

Abstract

Thirty-four adult and pediatric hemophilia A and B patients and 50 nonhemophilic members belonging to 28 families were enrolled in August 1984 in a study of human T cell lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) antibody status and T cell subpopulation numbers.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

HTLV-I antibody status in hemophilia patients treated with factor concentrates prepared from U.S. plasma sources and in hemophilia patients with AIDS

by

Abstract

Serum samples from 85 Austrian hemophilia patients treated with lyophilized factor concentrates prepared from U.S. plasma sources, 24 hemophilia patients from Georgia on a home therapy program with factor concentrates, and 10 U.S. hemophilia patients with acquired immunodeficiency syndrome (AIDS) were analyzed by two different methods for the presence of antibodies to the major internal antigen of human T-cell leukemia virus I (HTLV-I) p24.… Read more