variable beta chain

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Effects of HIV-1 peptides on T-cell receptor variable beta chain families

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Abstract

Superantigens (SAGs) selectively stimulate expansion and then deletion of specific T cell antigen receptor (TCR) variable beta chain (Vbeta) families. We investigated six synthetically produced HIV-1-related peptides for evidence of SAG activity: three derived all or in part from the transmembrane gp41 protein and three from the genetic sequence of the tRNA binding region.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Kawasaki disease and the T-cell antigen receptor

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Abstract

We investigated the evidence for an infectious etiology of Kawasaki disease (KD), an acute vasculitis of unknown etiology, by assessing the effects of KD on the T cell antigen receptor variable beta region families (V beta). Using 3-color flow cytometry, we studied KD patients pre- and post-intravenous gamma globulin (IVIG) therapy and at > 40 days post therapy, additionally comparing them to matched pediatric control patients (PCC) and their own healthy parents (one parent/KD child).… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

Immunoregulatory changes in Kawasaki disease

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Abstract

Kawasaki disease (KD) is an acute vasculitis of unknown etiology, occurring in young children and treated with intravenous gamma globulin (IVIG) to prevent significant cardiac morbidity and mortality. We studied KD patients pre- and post-IVIG therapy and at >40 days posttherapy, additionally comparing them with matched pediatric control patients and parents.… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

HIV antigens and T-cell receptor variable beta chain families

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Abstract

The authors investigated whether the human immunodeficiency virus (HIV) has restrictive effects on the variable region of the beta chain (V beta) of the T-cell antigen receptor (TCR), by in vitro cultivation of non-HIV-infected peripheral blood lymphocytes with one of six HIV antigens or heat-inactivated whole virus (HIV-HI).… Read more

Illustration(s) pertain to the topic addressed in this publication, not the specific research or data presented in the publication

The effects of mitogens, IL-2 and anti-CD3 antibody on the T-cell receptor V beta repertoire

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Abstract

Phytohaemagglutinin (PHA), Concanavalin A (Con A), interleukin-2 (IL-2), and monoclonal antibodies to CD3 (CD3MoAbs) are used for the assessment of the T-cell receptor (TCR) BV gene family expression in autoimmune disorders and multiple sclerosis, and to produce clones for assessment of cytokine profiles in progressive human immunodeficiency virus infection.… Read more